Article
Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.
The Journal of experimental medicine - 26 Aug 2013
Byun Minji, Ma Cindy S, Akçay Arzu, Pedergnana Vincent, Palendira Umaimainthan, Myoung Jinjong, Avery Danielle T, Liu Yifang, Abhyankar Avinash, Lorenzo Lazaro, Schmidt Monika, Lim Hye Kyung, Cassar Olivier, Migaud Melanie, Rozenberg Flore, Canpolat Nur, Aydogan Gönül, Fleckenstein Bernhard, Bustamante Jacinta, Picard Capucine, Gessain Antoine, Jouanguy Emmanuelle, Cesarman Ethel, Olivier Martin, Gros Philippe, Abel Laurent, Croft Michael, Tangye Stuart G, Casanova Jean-Laurent
Abstract excerpt
Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)-induced endothelial tumor, develops only in a small fraction of individuals infected with HHV-8. We hypothesized that inborn errors of immunity to HHV-8 might underlie the exceedingly rare development of classic KS in childhood...
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