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Article

Expression of Multidrug Resistance Genes in Normal and Cancer Stem Cells

1 Jan 2008

Abstract excerpt

CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in human glioblastoma and normal brain tissues. Glioma tissues contained higher ratio of CD133+ cells compared to normal tissues ( approximately 10 fold increase). The chemosensitivity assay showed that GOS-3 and NHA CD133+ possess greater resistance towards drugs compared to CD133- fractions. This study revealed for the first...

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PMID: 18568776
DOI: 10.1080/07357900801904140

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