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Article

Structural asymmetry of procaspase-7 bound to a specific inhibitor.

Acta crystallographica. Section D, Biological crystallography - 1 Aug 2013

Kang Hyo Jin, Lee Young-mi, Bae Kwang-Hee, Kim Seung Jun, Chung Sang J

Abstract excerpt

Caspase-7 is expressed as a proenzyme and is activated by initiator caspases upon the transmission of cell-death signals. Despite extensive structural and biochemical analyses, many questions regarding the mechanism of caspase-7 activation remain unanswered. Caspase-7 is auto-activated during overexpression in Escherichia coli, even in the absence of initiator caspases, indicating that procaspase-7 has intrinsic...

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Identifiers

PMID: 23897474
DOI: 10.1107/S0907444913010196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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