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Engineered hybrid dimers: tracking the activation pathway of caspase-7.

Molecular cell - 1 Aug 2006

Denault Jean-Bernard, Békés Miklós, Scott Fiona L, Sexton Kelly M B, Bogyo Matthew, Salvesen Guy S

Abstract excerpt

Caspase-7 is an obligate dimer of catalytic domains, with generation of activity requiring limited proteolysis within a region that separates the large and small chains of each domain. Using hybrid dimers we distinguish the relative contribution of each domain to catalysis by the whole molecule....

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Identifiers

PMID: 16916640
DOI: 10.1016/j.molcel.2006.06.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16916640-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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