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Article

L2' loop is critical for caspase-7 active site formation.

Protein science : a publication of the Protein Society - 1 Jul 2009

Witkowski Witold A, Hardy Jeanne A

Abstract excerpt

The active sites of caspases are composed of four mobile loops. A loop (L2) from one half of the dimer interacts with a loop (L2') from the other half of the dimer to bind substrate. In an inactive form, the two L2' loops form a cross-dimer hydrogen-bond network over the dimer interface. Although...

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Identifiers

PMID: 19530232
DOI: 10.1002/pro.151
PMCID: PMC2775214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19530232-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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