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The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light

7 Dec 2006

Abstract excerpt

p16INK4a and p21WAF1, two major cyclin-dependent kinase inhibitors, are the products of two tumor suppressor genes that play important roles in various cellular metabolic pathways. p21WAF1 is up-regulated in response to different DNA damaging agents. While the activation of p21WAF1 is p53-dependent following -rays, the effect of ultraviolet (UV) light on p21WAF1 protein level is still unclear. In the present...

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PMID: 17158160
DOI: 10.1093/nar/gkl1075

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