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Article

p16INK4A Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1

20 Jul 2011

Abstract excerpt

BACKGROUND: The cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and their functional interplay are still not well defined. METHODOLOGY/PRINCIPAL FINDINGS: We have shown here that the tumor suppressor p16(INK4a) protein positively...

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PMID: 21799732
DOI: 10.1371/journal.pone.0021111

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