Article
High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension.
Blood - 27 Aug 2009
Morris Timothy A, Marsh James J, Chiles Peter G, Magaña Marisa M, Liang Ni-Cheng, Soler Xavier, Desantis Daniel J, Ngo Debby, Woods Virgil L
Abstract excerpt
The mechanism by which chronic thromboembolic pulmonary hypertension (CTEPH) develops after acute pulmonary thromboembolism is unknown. We previously reported that fibrin from CTEPH patients is relatively resistant to fibrinolysis in vitro. In the present study, we performed proteomic, genomic, and functional studies on fibrin(ogen) to investigate whether abnormal fibrin(ogen) might contribute to the pathogenesis...
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