Article
Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis.
Scientific reports - 4 Oct 2016
Trentin Luca, Bresolin Silvia, Giarin Emanuela, Bardini Michela, Serafin Valentina, Accordi Benedetta, Fais Franco, Tenca Claudya, De Lorenzo Paola, Valsecchi Maria Grazia, Cazzaniga Giovanni, Kronnie Geertruy Te, Basso Giuseppe
Abstract excerpt
To induce and sustain the leukaemogenic process, MLL-AF4+ leukaemia seems to require very few genetic alterations in addition to the fusion gene itself. Studies of infant and paediatric patients with MLL-AF4+ B cell precursor acute lymphoblastic leukaemia (BCP-ALL) have reported mutations in KRAS and NRAS with incidences ranging from 25 to 50%. Whereas previous studies employed Sanger sequencing, here we used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.