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The Spectrum of MYC Alterations in Diffuse Large B-Cell Lymphoma.

Acta haematologica - 1 Jan 2020

Xia Yang, Zhang Xinlian

Abstract excerpt

MYC, as a powerful transcription factor, plays a vital role in various cancers. The clinical significance of MYC alterations in diffuse large B-cell lymphoma (DLBCL) has been investigated for a long time. In this study, we comprehensively summarize the different alterations of MYC in DLBCL, including MYC overexpression, MYC translocations, MYC mutations, and increased gene copy number of MYC. Noteworthy, lone MYC...

Topics

Antineoplastic Combined Chemotherapy Protocols
Apoptosis
Cyclophosphamide
Doxorubicin
Etoposide
Gene Dosage
Humans
Lymphoma, Large B-Cell, Diffuse
Mutation
Prednisolone
Prednisone
Proto-Oncogene Proteins c-bcl-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-bcl-6

Proto-Oncogene Proteins c-myc

Rituximab

Vincristine

Source

Identifiers

PMID: 32074595
DOI: 10.1159/000505892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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