Article
Minimal sequence variability of the region of HIV-1 integrase targeted by the Abbott RealTime HIV-1 viral load assay in clinical specimens with reduced susceptibility to raltegravir.
Journal of virological methods - 1 Nov 2013
Young Thomas P, Napolitano Laura A, Paquet Agnes C, Parkin Neil T, Fransen Signe, Trinh Roger, Haddad Mojgan, Hackett John, Cloherty Gavin A
Abstract excerpt
The Abbott RealTime (ART) HIV-1 assay targets the integrase region and is designed to tolerate mismatches. Variability in integrase sequences comprising the assay target regions from >1000 clinical specimens submitted for phenotypic and genotypic raltegravir resistance testing were analyzed. In t...
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