Article
The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein.
FEBS letters - 17 Sept 2013
Dutta Arpana, Chen Shugui, Surewicz Witold K
Abstract excerpt
Recent studies revealed that elk-like S170N/N174T mutation in mouse prion protein (moPrP), which results in an increased rigidity of β2-α2 loop, leads to a prion disease in transgenic mice. Here we characterized the effect of this mutation on biophysical properties of moPrP. Despite similar thermodynamic stabilities of wild type and mutant proteins, the latter was found to have markedly higher propensity to form...
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