Article
Epigenetics and MicroRNAs in Pharmacogenetics.
Advances in pharmacology (San Diego, Calif.) - 1 Jan 2018
Zanger Ulrich M, Klein Kathrin, Kugler Nicole, Petrikat Tamara, Ryu Chang S
Abstract excerpt
Germline pharmacogenetics has so far mainly studied common variants in "pharmacogenes," i.e., genes encoding drug metabolizing enzymes and transporters (DMET genes), certain auxiliary and regulatory genes, and drug target genes. Despite remarkable progress in understanding genetically determined differences in pharmacokinetics and pharmacodynamics of drugs, currently known common variants even in important...
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