Article
A novel transcriptional activator (PO-B) binds between the TATA box and cap site of the pro-opiomelanocortin gene.
Nucleic acids research - 11 Aug 1990
Riegel A T, Remenick J, Wolford R G, Berard D S, Hager G L
Abstract excerpt
We demonstrate that a factor (PO-B), detected in a number of mammalian cell lines, binds specifically between the TATA box and the transcription initiation site of the pituitary-specific pro-opiomelanocortin (POMC) gene. Methylation interference and DNAse 1 footprint analysis revealed that the binding site of this protein, -3 to -15, does not overlap the POMC TATA box or cap site. Mutation of the PO-B binding...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Deoxyribonuclease I
- Gene Expression Regulation
- HeLa Cells
- Humans
- Methylation
- Mice
- Molecular Sequence Data