Article
Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE study.
Schizophrenia research - 1 Sept 2013
Ramsey Timothy L, Liu Qian, Massey Bill W, Brennan Mark D
Abstract excerpt
Pharmacogenetic (PGx) predictors of response would improve outcomes in antipsychotic treatment. Based on both biological rationale and prior evidence of an impact on Parkinson's disease, we conducted an association study for 106 SNPs in the synaptic vesicle protein 2C (SV2C) gene using genetic and treatment response data from the Clinical Trial of Antipsychotic Intervention Effectiveness (CATIE). We examined...
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