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Article

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.

Scientific reports - 29 Jan 2018

Tögel Lars, Nightingale Rebecca, Wu Rui, Chüeh Anderly C, Al-Obaidi Sheren, Luk Ian, Dávalos-Salas Mercedes, Chionh Fiona, Murone Carmel, Buchanan Daniel D, Chatterton Zac, Sieber Oliver M, Arango Diego, Tebbutt Niall C, Williams David, Dhillon Amardeep S, Mariadason John M

Abstract excerpt

The ERK signalling pathway regulates key cell fate decisions in the intestinal epithelium and is frequently dysregulated in colorectal cancers (CRCs). Variations in the dynamics of ERK activation can induce different biological outcomes and are regulated by multiple mechanisms, including activation of negative feedback loops involving transcriptional induction of dual-specificity phosphatases (DUSPs). We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29379130
DOI: 10.1038/s41598-018-20176-9
PMCID: PMC5788859

Genes

DUSP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.PMID 29379130Read ↗

Downregulation of Dual-specificity phosphatase 9 promotes tumor progression and contributes to poor prognosis in colorectal cancerSemantic proximity Read ↗

NSUN2 drives intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signallingSemantic proximity Read ↗

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Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.Semantic proximity Read ↗

DUSP6 regulates Notch1 signalling in colorectal cancerSemantic proximity Read ↗

ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogationSemantic proximity Read ↗

DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancersSemantic proximity Read ↗

DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.Semantic proximity Read ↗

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Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathwaySemantic proximity Read ↗

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.Semantic proximity Read ↗

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