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Article

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.

Genes, chromosomes & cancer - 1 Nov 2010

Gaedcke Jochen, Grade Marian, Jung Klaus, Camps Jordi, Jo Peter, Emons Georg, Gehoff Anastasia, Sax Ulrich, Schirmer Markus, Becker Heinz, Beissbarth Tim, Ried Thomas, Ghadimi B Michael

Abstract excerpt

Mutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth factor receptor in patients with colorectal cancer. Overcoming this therapeutic dilemma could potentially be achieved by the introduction of drugs that inhibit signaling pathways that are activated by KRAS mutations. To identify comprehensively such signaling pathways, we profiled pretreatment...

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Source

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Identifiers

PMID: 20725992
DOI: 10.1002/gcc.20811
PMCID: PMC3535184

Genes

KRAS
DUSP4
SMYD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.PMID 20725992Read ↗

A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal CancerSemantic proximity Read ↗

Association of KRAS Mutation and Gene Pathways in Colorectal Carcinoma: A Transcriptome- and Methylome-Wide Study and Potential Implications for Therapy.Semantic proximity Read ↗

Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer.Semantic proximity Read ↗

KRAS mutations and CDKN2A promoter methylation show an interactive adverse effect on survival and predict recurrence of rectal cancer.Semantic proximity Read ↗

DUSP 4 expression identifies a subset of colorectal cancer tumors that differ in MAPK activation, regardless of the genotype.Semantic proximity Read ↗

Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.Semantic proximity Read ↗

Functional genomics identifies predictive markers and clinically actionable resistance mechanisms to CDK4/6 inhibition in bladder cancerSemantic proximity Read ↗

DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.Semantic proximity Read ↗

Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.Semantic proximity Read ↗

Genome-wide DNA methylation analysis of KRAS mutant cell lines.Semantic proximity Read ↗

PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1.Semantic proximity Read ↗

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.Semantic proximity Read ↗

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