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Article

Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.

International journal of cancer - 1 Apr 2013

Gröschl Benedikt, Bettstetter Marcus, Giedl Christian, Woenckhaus Matthias, Edmonston Tina, Hofstädter Ferdinand, Dietmaier Wolfgang

Abstract excerpt

DUSP4 (MKP-2), a member of the mitogen-activated protein kinase phosphatase (MKP) family and potential tumor suppressor, negatively regulates the MAPKs (mitogen-activated protein kinases) ERK, p38 and JNK. MAPKs play a crucial role in cancer development and progression. Previously, using microarr...

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Source

Identifiers

PMID: 22965873
DOI: 10.1002/ijc.27834

Genes

DUSP4
CCND1
EGR1
FOS
MSH2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22965873-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.PMID 22965873Read ↗

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