Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population.

doi:10.1016/j.cyto.2019.154956

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Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population.

Cytokine - 1 Mar 2020

Wang Wenfei, Deng Guofang, Zhang Guoliang, Yu Ziqi, Yang Fan, Chen Jianyong, Cai Yi, Werz Oliver, Chen Xinchun

Abstract excerpt

Th17 cells play a key role in immunity against Mycobacterium tuberculosis, our previous research showed that reduced Th17 responses were associated with the severe outcome of Mtb infection. The associations between IL17A polymorphisms and susceptibility of TB has been reported, but the results are inconsistent and the underlying mechanisms is unknown. In this study, we identified a genetic variation (rs8193036)...

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PMID: 31864094
DOI: 10.1016/j.cyto.2019.154956

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