Article
The first mecp2-null zebrafish model shows altered motor behaviors.
Frontiers in neural circuits - 1 Jan 2013
Pietri Thomas, Roman Angel-Carlos, Guyon Nicolas, Romano Sebastián A, Washbourne Philip, Moens Cecilia B, de Polavieja Gonzalo G, Sumbre Germán
Abstract excerpt
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder and one of the most common causes of mental retardation in affected girls. Other symptoms include a rapid regression of motor and cognitive skills after an apparently early normal development. Sporadic mutations in the transcription factor MECP2 has been shown to be present in more than 90% of the patients and several models of MeCP2-deficient mice...
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