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Article

Single-cell gene expression analysis reveals genetic associations masked in whole-tissue experiments.

Nature biotechnology - 1 Aug 2013

Wills Quin F, Livak Kenneth J, Tipping Alex J, Enver Tariq, Goldson Andrew J, Sexton Darren W, Holmes Chris

Abstract excerpt

Gene expression in multiple individual cells from a tissue or culture sample varies according to cell-cycle, genetic, epigenetic and stochastic differences between the cells. However, single-cell differences have been largely neglected in the analysis of the functional consequences of genetic variation. Here we measure the expression of 92 genes affected by Wnt signaling in 1,440 single cells from 15 individuals...

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PMID: 23873083
DOI: 10.1038/nbt.2642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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