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Article

Titanium uptake, induction of RANK-L expression, and enhanced proliferation of human T-lymphocytes.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 2010

Cadosch Dieter, Sutanto Michael, Chan Erwin, Mhawi Amir, Gautschi Oliver P, von Katterfeld Brilliana, Simmen Hans-Peter, Filgueira Luis

Abstract excerpt

There is increasing evidence that titanium ions are released from orthopedic implants by biocorrosion. The aim of this study was to investigate titanium uptake by human T-lymphocytes and its effects on phenotype and proliferation. Freshly isolated human nonadherent peripheral blood mononuclear cells (NA-PBMC), were exposed to TiCl4 [Ti(IV)]. Bioavailability and distribution of Ti(IV) in T-lymphocytes was...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19810098
DOI: 10.1002/jor.21013

Genes

CCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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