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Article

FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery.

JCI insight - 1 Aug 2024

Li Guanya, Hu Yang, Zhang Wenchao, Wang Jia, Sun Lijuan, Yu Juan, Manza Peter, Volkow Nora D, Ji Gang, Wang Gene-Jack, Zhang Yi

Abstract excerpt

BACKGROUNDA polymorphism in the fat mass and obesity-associated gene (FTO) is linked to enhanced neural sensitivity to food cues and attenuated ghrelin suppression. Risk allele carriers regain more weight than noncarriers after bariatric surgery. It remains unclear how FTO variation affects brain function and ghrelin following surgery.METHODSResting-state functional magnetic resonance imaging and cue-reactivity...

Topics

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Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Bariatric Surgery
Body Mass Index
Ghrelin
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Obesity, Morbid

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Open in PubMed Open full text

Identifiers

PMID: 39088267
DOI: 10.1172/jci.insight.175967
PMCID: PMC11385082

Genes

FTO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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FTO variant is associated with changes in BMI, ghrelin, and brain function following bariatric surgery.PMID 39088267Read ↗

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