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Article

Non-coding RNAs regulate autophagy in kidney disease: friend or foe?

25 Aug 2025

Abstract excerpt

Macroautophagy/autophagy is a conserved cellular process that degrades misfolded proteins and damaged organelles to regulate cell survival and division. Normal levels of autophagy are observed in healthy kidney cells. In contrast, excessive or insufficient autophagy is observed during kidney disease progression. However, canonical treatments that regulate autophagy using chemical reagents may induce unexpected...

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PMID: 40851276
DOI: 10.1080/15548627.2025.2551683

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