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Article

Targeting Autophagy in Cancer: Recent Advances and Future Directions.

Cancer discovery - 1 Sept 2019

Amaravadi Ravi K, Kimmelman Alec C, Debnath Jayanta

Abstract excerpt

Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit the growth of established tumors and improve response to cancer therapeutics. Certain cancer genotypes may...

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Identifiers

PMID: 31434711
DOI: 10.1158/2159-8290.CD-19-0292
PMCID: PMC7306856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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