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Article

Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.

Scientific reports - 2 Jul 2018

Yu Zhou, Ma Jing, Li Xia, Liu Yixiong, Li Mingyang, Wang Lu, Zhao Ming, He Huiying, Zhang Yifen, Rao Qiu, Zhao Danhui, Wang Yingmei, Fan Linni, Li Peifeng, Liu Yang, Liu Fang, Zhang Feng, Ye Jing, Yan Qingguo, Guo Shuangping, Wang Zhe

Abstract excerpt

The relationship between autophagy and tumour is well studied, but tumour cell morphological changes associated with autophagy defects are rarely reported, especially in renal cell carcinoma (RCC). We collected 10 renal tumour samples with characteristic eosinophilic cytoplasmic inclusions (ECIs) and found that the ECIs were majorly composed of sequestosome 1/P62, neighbor of BRCA1 gene 1 (NBR1), PEX14, and...

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Identifiers

PMID: 29967346
DOI: 10.1038/s41598-018-28369-y
PMCID: PMC6028630

Genes

ATG10
ATG5
ATG7
BRCA1
NBR1
PEX14

Provenance

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