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Article

pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2013

Sheen Patricia, Lozano Katherine, Gilman Robert H, Valencia Hugo J, Loli Sebastian, Fuentes Patricia, Grandjean Louis, Zimic Mirko

Abstract excerpt

Mutations in the pyrazinamidase (PZAse) coding gene, pncA, have been considered as the main cause of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis. However, recent studies suggest there is no single mechanism of resistance to PZA. The pyrazinoic acid (POA) efflux rate is the basis of the PZA susceptibility Wayne test, and its quantitative measurement has been found to be a highly sensitive and...

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Identifiers

PMID: 23867321
DOI: 10.1016/j.tube.2013.03.005
PMCID: PMC3755357

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