Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2009

Sheen Patricia, Ferrer Patricia, Gilman Robert H, López-Llano Jon, Fuentes Patricia, Valencia Eddy, Zimic Mirko J

Abstract excerpt

Resistance of Mycobacterium tuberculosis to pyrazinamide is associated with mutations in the pncA gene, which codes for pyrazinamidase. The association between the enzymatic activity of mutated pyrazinamidases and the level of pyrazinamide resistance remains poorly understood. Twelve M. tuberculosis clinical isolates resistant to pyrazinamide were selected based on Wayne activity and localization of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Mycobacterium tuberculosis

Share to Pyrazinamide

Share to Recombinant Proteins

Share to Sputum

Source

Open in PubMed Open full text

Identifiers

PMID: 19249243
DOI: 10.1016/j.tube.2009.01.004
PMCID: PMC2691962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of pyrazinamidase activity on pyrazinamide resistance in Mycobacterium tuberculosis.PMID 19249243Read ↗

Kinetical Analysis of Mutant PZase Enzyme To Uncover The Pyrazinamide Resistance In Mycobacterium tuberculosis Clinical Isolates.Semantic proximity Read ↗

Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis.Semantic proximity Read ↗

pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Systematic review of mutations in pyrazinamidase associated with pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates.Semantic proximity Read ↗

Mutations found in the pncA gene of Mycobacterium tuberculosis in clinical pyrazinamide-resistant isolates from a local region of China.Semantic proximity Read ↗

Biochemical Characterization and Computational Identification of Mycobacterium tuberculosis Pyrazinamidase in Some Pyrazinamide-Resistant Isolates of Iran.Semantic proximity Read ↗

pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of BrazilSemantic proximity Read ↗

Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update.Semantic proximity Read ↗

Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.Semantic proximity Read ↗

Correlation of pncA sequence with pyrazinamide resistance level in BACTEC for 21 mycobacterium tuberculosis clinical isolates.Semantic proximity Read ↗

Pyrazinoic acid efflux rate in Mycobacterium tuberculosis is a better proxy of pyrazinamide resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.