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Kinetical Analysis of Mutant PZase Enzyme To Uncover The Pyrazinamide Resistance In Mycobacterium tuberculosis Clinical Isolates.

The new microbiologica - 1 Jul 2026

Purkan Purkan, Nadila Alivia, Nabilah Bilqis Aliifa, Sujatha R Merlyn, Retnowati Wiwin, Pudjiastuti Pratiwi, Hadi Sofijan

Abstract excerpt

Mutations in the pncA gene of Mycobacterium tuberculosis, which encodes the PZase enzyme, are closely linked to pyrazinamide (PZA) resistance. Two clinical isolates, R1 and R2, which are resistant to pyrazinamide at concentrations of 100 μg/mL and 150 μg/mL, respectively, harbor multiple pncA mutations. The pncA R1 gene carries T41C, G419A, and A535G, causing Cys14Arg, Arg140His, and Ser179Gly substitutions in...

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PMID: 42507121

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