Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum.

Malaria journal - 17 Jul 2013

Flegg Jennifer A, Patil Anand P, Venkatesan Meera, Roper Cally, Naidoo Inbarani, Hay Simon I, Sibley Carol Hopkins, Guerin Philippe J

Abstract excerpt

BACKGROUND: Plasmodium falciparum has repeatedly evolved resistance to first-line anti-malarial drugs, thwarting efforts to control and eliminate the disease and in some period of time this contributed largely to an increase in mortality. Here a mathematical model was developed to map the spatiot...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa South of the Sahara
Share to Antimalarials
Share to Dihydropteroate Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Models, Theoretical

Share to Mutation Rate

Share to Plasmodium falciparum

Share to Sulfadoxine

Source

Open in PubMed Open full text

Identifiers

PMID: 23866695
DOI: 10.1186/1475-2875-12-249
PMCID: PMC3728261

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23866695-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum.PMID 23866695Read ↗

Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990-2020.Semantic proximity Read ↗

Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa.Semantic proximity Read ↗

Mapping partner drug resistance to guide antimalarial combination therapy policies in sub-Saharan Africa.Semantic proximity Read ↗

Regional Patterns and Temporal Trends of Pfdhfr and Pfdhps Markers of Antifolate Resistance in Plasmodium falciparum in East and West Africa, 2010-2025: A Systematic Review.Semantic proximity Read ↗

A spatio-temporal model of multi-marker antimalarial resistance.Semantic proximity Read ↗

Drug resistance maps to guide intermittent preventive treatment of malaria in African infants.Semantic proximity Read ↗

Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.Semantic proximity Read ↗

Multiple origins and regional dispersal of resistant dhps in African Plasmodium falciparum malaria.Semantic proximity Read ↗

Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across AfricaSemantic proximity Read ↗

Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study.Semantic proximity Read ↗

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations.Semantic proximity Read ↗

The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.