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Article

Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.

PloS one - 1 Jan 2012

Moumné Lara, Campbell Ken, Howland David, Ouyang Yingbin, Bates Gillian P

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by an expansion of a CAG/polyglutamine repeat for which there are no disease modifying treatments. In recent years, transcriptional dysregulation has emerged as a pathogenic process that appears early in disease progression and has been recapitulated across multiple HD models. Altered histone acetylation has been...

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Source

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Identifiers

PMID: 22347433
DOI: 10.1371/journal.pone.0031080
PMCID: PMC3275566

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.PMID 22347433Read ↗

Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.Semantic proximity Read ↗

Selective inhibition of histone deacetylase 1 and 3 improves motor phenotype and alleviates transcriptional dysregulation in Huntington’s disease miceSemantic proximity Read ↗

Evaluation of Histone Deacetylases as Drug Targets in Huntington’s Disease modelsStudy of HDACs in brain tissues from R6/2 and CAG140 knock-in HD mouse models and human patients and in a neuronal HD cell model.Semantic proximity Read ↗

The Effects of Selective Inhibition of Histone Deacetylase 1 and 3 in Huntington’s Disease MiceSemantic proximity Read ↗

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Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease miceSemantic proximity Read ↗

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