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Article

Gene expression profiles in febrile children with defined viral and bacterial infection

15 Jul 2013

Abstract excerpt

Viral infections are common causes of fever without an apparent source in young children. Despite absence of bacterial infection, many febrile children are treated with antibiotics. Virus and bacteria interact with different pattern recognition receptors in circulating blood leukocytes, triggering specific host transcriptional programs mediating immune response. Therefore, unique transcriptional signatures may be...

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PMID: 23858444
DOI: 10.1073/pnas.1302968110

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