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Article

Host-response transcriptional biomarkers accurately discriminate bacterial and viral infections of global relevance

18 Dec 2023

Abstract excerpt

Diagnostic limitations challenge management of clinically indistinguishable acute infectious illness globally. Gene expression classification models show great promise distinguishing causes of fever. We generated transcriptional data for a 294-participant (USA, Sri Lanka) discovery cohort with adjudicated viral or bacterial infections of diverse etiology or non-infectious disease mimics. We then derived and...

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PMID: 38110534
DOI: 10.1038/s41598-023-49734-6

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