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Article

Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer.

The Journal of clinical endocrinology and metabolism - 1 Sept 2013

Feng Chen, Gao Yun, Wang Cuifang, Yu Xiaohui, Zhang Wei, Guan Haixia, Shan Zhongyan, Teng Weiping

Abstract excerpt

CONTEXT: Many tumor cells predominantly generate energy through high rates of glycolysis. Pyruvate kinase M2 (PKM2) has been identified as being necessary for aerobic glycolysis. OBJECTIVE: The aim of this study was to investigate the expression pattern of PKM2 in papillary thyroid cancer (PTC) and the possible role of PKM2 in PTC. DESIGN: The expression of PKM2 in human thyroid tissues was examined using...

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Share to Adenosine Triphosphate
Share to Carcinoma, Papillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23846818
DOI: 10.1210/jc.2012-4258

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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