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Article

Pharmacogenetics of tamoxifen therapy in Asian populations: from genetic polymorphism to clinical outcomes.

European journal of clinical pharmacology - 1 Aug 2021

Wang Tingyu, Zhou Yitian, Cao Guosheng

Abstract excerpt

BACKGROUND: Compared with western countries, Asian breast cancer patients have unique pathological and biological characteristics. Most of them are premenopausal women with HR positive. Tamoxifen as the first-line drug for premenopausal women with HR+ is involved in multiple enzymes and transporters during metabolizing and transporting process. Variants that cause decreased or inactive gene products leading to...

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Share to Antineoplastic Agents, Hormonal
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P450 Family 2

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Share to Liver-Specific Organic Anion Transporter 1

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Source

Identifiers

PMID: 33515076
DOI: 10.1007/s00228-021-03088-y

Genes

ABCB1
CYP2C9
SLCO1B1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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