Article
CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2013
Goetz Matthew P, Suman Vera J, Hoskin Tanya L, Gnant Michael, Filipits Martin, Safgren Stephanie L, Kuffel Mary, Jakesz Raimund, Rudas Margaretha, Greil Richard, Dietze Otto, Lang Alois, Offner Felix, Reynolds Carol A, Weinshilboum Richard M, Ames Matthew M, Ingle James N
Abstract excerpt
PURPOSE: Controversy exists about CYP2D6 genotype and tamoxifen efficacy. EXPERIMENTAL DESIGN: A matched case-control study was conducted using the Austrian Breast and Colorectal Cancer Study Group Trial 8 (ABCSG8) that randomized postmenopausal women with estrogen receptor (ER)-positive breast cancer to tamoxifen for 5 years (arm A) or tamoxifen for 2 years followed by anastrozole for 3 years (arm B). Cases had...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.