Article
A Novel Stratification Method in Linkage Studies to Address Inter- and Intra-Family Heterogeneity in Autism.
PloS one - 1 Jan 2013
Talebizadeh Zohreh, Arking Dan E, Hu Valerie W
Abstract excerpt
Most genome linkage scans for autism spectrum disorders (ASDs) have failed to be replicated. Recently, a new ASD phenotypic sub-classification method was developed which employed cluster analyses of severity scores from the Autism Diagnostic Interview-Revised (ADI-R). Here, we performed linkage analysis for each of the four identified ADI-R stratified subgroups. Additional stratification was also applied to...
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