Article
Family-Based Genome-Wide Association Study of Autism Spectrum Disorder in Middle Eastern Families.
Genes - 18 May 2021
Al-Sarraj Yasser, Al-Dous Eman, Taha Rowaida Z, Ahram Dina, Alshaban Fouad, Tolfat Mohammed, El-Shanti Hatem, Albagha Omar M E
Abstract excerpt
Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by abnormalities in language and social communication with substantial clinical heterogeneity. Genetic factors play an important role in ASD with heritability estimated between 70% to 80%. Genome-wide association studies (GWAS) have identified multiple loci associated with ASD. However, most studies were performed on European populations...
Topics
- Adult
- Autism Spectrum Disorder
- Case-Control Studies
- Child
- Female
- Gene Expression
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Middle East