Clustering by phenotype and genome-wide association study in autism.

doi:10.1038/s41398-020-00951-x

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Clustering by phenotype and genome-wide association study in autism.

Translational psychiatry - 17 Aug 2020

Narita Akira, Nagai Masato, Mizuno Satoshi, Ogishima Soichi, Tamiya Gen, Ueki Masao, Sakurai Rieko, Makino Satoshi, Obara Taku, Ishikuro Mami, Yamanaka Chizuru, Matsubara Hiroko, Kuniyoshi Yasutaka, Murakami Keiko, Ueno Fumihiko, Noda Aoi, Kobayashi Tomoko, Kobayashi Mika, Usuzaki Takuma, Ohseto Hisashi, Hozawa Atsushi, Kikuya Masahiro, Metoki Hirohito, Kure Shigeo, Kuriyama Shinichi

Abstract excerpt

Autism spectrum disorder (ASD) has phenotypically and genetically heterogeneous characteristics. A simulation study demonstrated that attempts to categorize patients with a complex disease into more homogeneous subgroups could have more power to elucidate hidden heritability. We conducted cluster analyses using the k-means algorithm with a cluster number of 15 based on phenotypic variables from the Simons Simplex...

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PMID: 32807774
DOI: 10.1038/s41398-020-00951-x
PMCID: PMC7431539

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