Article
Association between an Alzheimer's Disease-Related Index and APOE ε4 Gene Dose.
PloS one - 1 Jan 2013
Schraml Frank, Chen Kewei, Ayutyanont Napatkamon, Auttawut Roontiva, Langbaum Jessica B S, Lee Wendy, Liu Xiaofen, Bandy Dan, Reeder Stephanie Q, Alexander Gene E, Caselli Richard J, Fleisher Adam S, Reiman Eric M
Abstract excerpt
BACKGROUND: We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in cognitively normal...
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