Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.

Clinical pharmacology and therapeutics - 1 Oct 2013

Yerges-Armstrong L M, Ellero-Simatos S, Georgiades A, Zhu H, Lewis J P, Horenstein R B, Beitelshees A L, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner A R, Kaddurah-Daouk R

Abstract excerpt

Although aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples, enabling detailed mapping of pathways involved in drug response. We defined the metab...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Aspirin
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metabolomics

Share to Platelet Aggregation Inhibitors

Share to Purines

Source

Open in PubMed Open full text

Identifiers

PMID: 23839601
DOI: 10.1038/clpt.2013.119
PMCID: PMC4001726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23839601-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.PMID 23839601Read ↗

Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.Semantic proximity Read ↗

Pharmacogenomics in aspirin intolerance.Semantic proximity Read ↗

Pharmacometabolomics analysis of plasma to phenotype clopidogrel high on treatment platelets reactivity in coronary artery disease patients.Semantic proximity Read ↗

Aspirin protects some hearts better than others. It's in the genes. A biomarker can predict a person's response to this potentially lifesaving medication.Semantic proximity Read ↗

Aspirin and Cancer: An Updated MinireviewSemantic proximity Read ↗

Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).Semantic proximity Read ↗

Molecular genomic and epigenomic characteristics related to aspirin and clopidogrel resistanceSemantic proximity Read ↗

Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1.Semantic proximity Read ↗

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2).Semantic proximity Read ↗

Integration of Pharmacometabolomic and Pharmacogenomic Approaches Reveals Novel Insights Into Antiplatelet TherapySemantic proximity Read ↗

Systems Pharmacogenomics Finds RUNX1 Is an Aspirin-Responsive Transcription Factor Linked to Cardiovascular Disease and Colon Cancer.Semantic proximity Read ↗

The emergent phenomenon of aspirin resistance: insights from genetic association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.