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Article

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2).

The Journal of biological chemistry - 26 Apr 2013

Zhou Gang, Marathe Gopal K, Hartiala Jaana, Hazen Stanley L, Allayee Hooman, Tang W H Wilson, McIntyre Thomas M

Abstract excerpt

Aspirin is rapidly hydrolyzed within erythrocytes by a heterodimer of PAFAH1b2/PAFAH1b3 but also in plasma by an unidentified activity. Hydrolysis in both compartments was variable, with a 12-fold variation in plasma among 2226 Cleveland Clinic GeneBank patients. Platelet inhibition by aspirin was suppressed in plasma that rapidly hydrolyzed aspirin. Plasma aspirin hydrolysis was significantly higher in patients...

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Identifiers

PMID: 23508960
DOI: 10.1074/jbc.M112.427674
PMCID: PMC3636881

Genes

BCHE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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