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Article

Pharmacometabolomics analysis of plasma to phenotype clopidogrel high on treatment platelets reactivity in coronary artery disease patients.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 30 May 2018

Amin Arwa M, Sheau Chin Lim, Teh Chin-Hoe, Mostafa Hamza, Mohamed Noor Dzul Azri, Abdul Kader Muhamad Ali S K, Kah Hay Yuen, Ibrahim Baharudin

Abstract excerpt

Dual antiplatelet therapy (DAPT) of clopidogrel and aspirin is crucial for coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). However, some patients may endure clopidogrel high on treatment platelets reactivity (HTPR) which may cause thromboembolic events. Clopidogrel HTPR is multifactorial with some genetic and non-genetic factors contributing to it. We aimed to use...

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PMID: 29526765
DOI: 10.1016/j.ejps.2018.03.011

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CAD

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