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Article

Aspirin effects on platelet gene expression are associated with a paradoxical, increase in platelet function.

2021-07-23

Abstract excerpt

Aspirin has known effects beyond inhibiting platelet cyclooxygenase-1 (COX1) that have been incompletely characterized. Transcriptomics can comprehensively characterize the on- and off-target effects of medications. We used a systems pharmacogenomics approach of aspirin exposure in volunteers coupled with serial platelet function and purified platelet mRNA sequencing to test the hypothesis that aspirin’s effects o...

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Literature Corpus work
c35d430c-d529-54dd-801d-66d91947fce0
DOI
10.22541/au.162703929.98672324/v1
Open publication

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