Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background.

doi:10.1016/j.cancergen.2012.01.009

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Article

Pheochromocytoma and paraganglioma: understanding the complexities of the genetic background.

Cancer genetics - 1 Jan 2000

Fishbein Lauren, Nathanson Katherine L

Abstract excerpt

Pheochromocytomas and paragangliomas (PCC/PGL) are tumors derived from the adrenal medulla or extra-adrenal ganglia, respectively. They are rare and often benign tumors that are associated with high morbidity and mortality due to mass effect and high circulating catecholamines. Although most PCCs and PGLs are thought to be sporadic, over one third are associated with 10 known susceptibility genes. Mutations in...

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