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Article

Impact of fluoroquinolone resistance on bactericidal and sterilizing activity of a moxifloxacin-containing regimen in murine tuberculosis.

Antimicrobial agents and chemotherapy - 1 Sept 2013

Fillion Aurélie, Aubry Alexandra, Brossier Florence, Chauffour Aurélie, Jarlier Vincent, Veziris Nicolas

Abstract excerpt

It has been shown previously that fluoroquinolone resistance (defined by resistance to at least 2 mg/liter ofloxacin) has a different impact on moxifloxacin monotherapy depending on the mutation in the sole fluoroquinolone target in Mycobacterium tuberculosis, i.e., DNA gyrase. Since tuberculosis treatment relies on multidrug therapy, we wished to determine the impact of fluoroquinolone resistance on the...

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Identifiers

PMID: 23836169
DOI: 10.1128/AAC.00506-13
PMCID: PMC3754299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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