Article
RNA interference suppression of A100A4 reduces the growth and metastatic phenotype of human renal cancer cells via NF-kB-dependent MMP-2 and bcl-2 pathway.
European review for medical and pharmacological sciences - 1 Jun 2013
Yang X-C, Wang X, Luo L, Dong D-H, Yu Q-C, Wang X-S, Zhao K
Abstract excerpt
BACKGROUND AND AIM: S100A4 is a well established marker and mediator of metastatic disease, but the exact mechanisms responsible for the metastasis promoting effects are less well defined. We tested a hypothesis that the S100A4 gene plays a role in the proliferation and invasiveness of human renal cancer cells (RCC) and may be associated with its metastatic spread. MATERIALS AND METHODS: The small interference...
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