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Article

Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes.

Cancer research - 1 Nov 2008

Cao Ying, Wang Ling, Nandy Debashis, Zhang Ying, Basu Ananda, Radisky Derek, Mukhopadhyay Debabrata

Abstract excerpt

Expression of neuropilin-1 (NRP-1) has been shown in many cancer cells, but its molecular effect on tumorigenesis is largely unknown. In this report, we show that in aggressive types of renal cell carcinoma (RCC), NRP-1 is expressed at a high level. We show that after knockdown of NRP-1 by short...

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Identifiers

PMID: 18974107
DOI: 10.1158/0008-5472.CAN-08-2614
PMCID: PMC3964774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18974107-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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