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Article

Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations.

Nature communications - 18 Apr 2016

Zhai Liting, Feng Lingling, Xia Lin, Yin Huiyong, Xiang Song

Abstract excerpt

Glycogen is a branched glucose polymer and serves as an important energy store. Its debranching is a critical step in its mobilization. In animals and fungi, the 170 kDa glycogen debranching enzyme (GDE) catalyses this reaction. GDE deficiencies in humans are associated with severe diseases collectively termed glycogen storage disease type III (GSDIII). We report crystal structures of GDE and its complex with...

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Identifiers

PMID: 27088557
DOI: 10.1038/ncomms11229
PMCID: PMC4837477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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