Essential role of arginine 320 in L. donovani quinone oxidoreductase catalysis: Implications for therapeutic approaches.

doi:10.1016/j.bbrc.2026.154093

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Article

Essential role of arginine 320 in L. donovani quinone oxidoreductase catalysis: Implications for therapeutic approaches.

Biochemical and biophysical research communications - 27 Aug 2026

Sahu Shivam, Upadhyay Aastha, Kamei Suamreiliu, Vishwakarma Chandan, Pratap J Venkatesh

Abstract excerpt

Quinone oxidoreductases (QORs) play an essential protective role in cellular detoxification by reducing quinones to their less reactive hydroxyquinones. In Leishmania donovani, QOR (LdQOR) constitutes an important component of the parasite's antioxidant defence machinery, however, its enzymatic characteristics and catalytic mechanism remain poorly understood. Mutant constructs of LdQOR key active site residues...

Topics

Arginine
Leishmania donovani
Catalytic Domain
Catalysis
Kinetics
NAD(P)H Dehydrogenase (Quinone)
Mutation

Source

Open in PubMed

Identifiers

PMID: 42247813
DOI: 10.1016/j.bbrc.2026.154093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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